Hydrazine hydrate (1:1) → HCID 86685993, compound

HRID 2277699Notes

Reaction equation

HRID 2277699 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[C:9]([N:11]2[CH2:20][CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([Cl:21])[CH:17]=3)[C:12]2=[O:22])[CH:10]=1.O.[NH2:25][NH2:26]>C(O)C>[Cl:21][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[C:12](=[O:22])[N:11]([C:9]1[CH:10]=[C:5]([CH2:4][C:3]([NH:25][NH2:26])=[O:2])[CH:6]=[N:7][CH:8]=1)[CH2:20][CH2:19]2

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86685992HCID 86685992, compound

Product 1

HCID 86685993HCID 86685993, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

[5-(6-Chloro-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-pyridin-3-yl]-acetic acid methyl ester (100 mg, 0.30 mmol) and hydrazine monohydrate (0.75 mL) were dissolved in ethanol (8.0 mL) and the reaction mixture was heated at 90° C. for 3 h before it was cooled and concentrated in vacuo to give a crude product (100 mg, quant.) as light yellow oil. MS: 331.1 (M+H+).

Workup

  1. temperaturewas cooled
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-df9eecf2fdb442a69d8d11dd31f65da1
Source dataset
uspto-grants-2015_09
Patent number
US09133158B2

Reaction notes

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