2-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine → HCID 89444759, compound

HRID 2277763Notes

Reaction equation

HRID 2277763 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[O:15][CH3:16])[C:5]([F:17])=[CH:4][N:3]=1.[CH:18]1([S:21][CH2:22][C:23]2[CH:24]=[C:25]([CH:27]=[CH:28][CH:29]=2)[NH2:26])[CH2:20][CH2:19]1>>[CH:18]1([S:21][CH2:22][C:23]2[CH:24]=[C:25]([NH:26][C:2]3[N:7]=[C:6]([C:8]4[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=4[O:15][CH3:16])[C:5]([F:17])=[CH:4][N:3]=3)[CH:27]=[CH:28][CH:29]=2)[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 867296092-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidineHCID 89239811HCID 89239811, compound

Product 1

HCID 89444759HCID 89444759, compound

Procedure

Intermediate 48.3 was prepared under similar conditions as described in the preparation of Intermediate 20.1 using 2-chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine and 3-[(cyclopropylsulfanyl)-methyl]aniline. The batch was purified by chromatography (hexane/ethyl acetate 30%) to give the desired product.

Workup

  1. customThe batch was purified by chromatography (hexane/ethyl acetate 30%)

Sources & evidence

ORD record
ord-5d873d15b88d4d62b0856e151e3eda77
Source dataset
uspto-grants-2015_09
Patent number
US09133171B2

Reaction notes

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