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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2277763Generated: November 1, 2026

2-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine → HCID 89444759, compound

https://huagongshe.com/reaction/2277763

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidineHCID 86729609—
ReactantHCID 89239811HCID 89239811—
ProductHCID 89444759HCID 89444759—

Reaction Steps

Intermediate 48.3 was prepared under similar conditions as described in the preparation of Intermediate 20.1 using 2-chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine and 3-[(cyclopropylsulfanyl)-methyl]aniline. The batch was purified by chromatography (hexane/ethyl acetate 30%) to give the desired product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09133171B2
Source datasetuspto-grants-2015_09
ORD IDord-5d873d15b88d4d62b0856e151e3eda77
Source noteuspto-grants-2015_09