2-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine → HCID 89444641, compound

HRID 2277767Notes

Reaction equation

HRID 2277767 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[O:15][CH3:16])[C:5]([F:17])=[CH:4][N:3]=1.[CH3:18][C:19]1[CH:20]=[C:21]([CH:23]=[C:24]([CH2:26][S:27][CH3:28])[CH:25]=1)[NH2:22]>>[F:17][C:5]1[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[O:15][CH3:16])=[N:7][C:2]([NH:22][C:21]2[CH:23]=[C:24]([CH2:26][S:27][CH3:28])[CH:25]=[C:19]([CH3:18])[CH:20]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 867296092-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidineHCID 89262622HCID 89262622, compound

Product 1

HCID 89444641HCID 89444641, compound

Procedure

Intermediate 58.3 was prepared under similar conditions as described in the preparation of Intermediate 20.1 using 2-chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine and 3-methyl-5-[(methyl-sulfanyl)methyl]aniline. The batch was purified by chromatography (hexane/ethyl acetate 5% to 32%) to give the desired product.

Workup

  1. customThe batch was purified by chromatography (hexane/ethyl acetate 5% to 32%)

Sources & evidence

ORD record
ord-23bbb9b3db7c43308c3e1b85360cae55
Source dataset
uspto-grants-2015_09
Patent number
US09133171B2

Reaction notes

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