Pyrrolidine → HCID 57326630, compound

HRID 2278209Notes

Reaction equation

HRID 2278209 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4](F)[CH:3]=1.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:3]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 27249084-Chloro-2-fluorobenzaldehyde

Product 1

HCID 57326630HCID 57326630, compound

Procedure

The title compound was prepared from 4-chloro-2-fluorobenzaldehyde and pyrroldine according to the representative procedures of Example 56, Step 1: 1H NMR 400 MHz (CDCl3) δ 10.04 (s, 1H), 7.64 (d, J=8.1 Hz, 1H), 6.82 (s, 1H), 6.77 (d, J=8.4 Hz, 1H), 3.41-3.33 (m, 4H), 2.06-1.96 (m, 4H). LCMS (ESI, m/z): 210 [M+H]+.

Sources & evidence

ORD record
ord-ac583ca3fd6d4b6fa8eb249ac0959955
Source dataset
uspto-grants-2015_09
Patent number
US09133148B2

Reaction notes

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