Water → HCID 89525727, compound

HRID 2278363Notes

Reaction equation

HRID 2278363 reaction equation
CC1(C)CO[CH:5]([C:8]2[S:12][CH:11]=[C:10]([CH:13]([N:16]([CH2:26][CH2:27][CH:28]([CH3:30])[CH3:29])[S:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)(=[O:19])=[O:18])[CH2:14][OH:15])[CH:9]=2)[O:4]C1.O>CC(O)=O.O>[CH:5]([C:8]1[S:12][CH:11]=[C:10]([CH:13]([N:16]([CH2:26][CH2:27][CH:28]([CH3:30])[CH3:29])[S:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)(=[O:18])=[O:19])[CH2:14][OH:15])[CH:9]=1)=[O:4]

Participants

4

Reactant 2

HCID 962WaterHCID 89525767HCID 89525767, compound

Product 1

HCID 89525727HCID 89525727, compound

Reagents, catalysts & solvents 1

HCID 21899381Acetic acid--water (1/1)Solvent

Procedure

N-{1-[5-(5,5-dimethyl-1,3-dioxan-2-yl)thiophen-3-yl]-2-hydroxyethyl}-N-(3-methylbutyl)benzenesulfonamide was dissolved in 10 mL AcOH/water (4:1) and stirred for 5 hours. 5 mL of water was and the aqueous layer was extracted 2× with EtOAc. The EtOAc layers were combined, washed 3 times with water, once with brine and dried (MgSO4). The residue was purified on silica gel (EtOAc/hexanes).

Workup

  1. extractionthe aqueous layer was extracted 2× with EtOAc
  2. washwashed 3 times with water
  3. dry with materialonce with brine and dried (MgSO4)
  4. customThe residue was purified on silica gel (EtOAc/hexanes)

Sources & evidence

ORD record
ord-aedb8a04ad514288a582ad5d7ede3895
Source dataset
uspto-grants-2015_09
Patent number
US09133157B2

Reaction notes

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