Hydrochloric Acid → HCID 117629145, compound

Participants

Reaction Steps

To a solution of N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-(5-{[(tert-butylsulfinyl)amino]methyl}thiophen-2-yl)ethyl]-N-(2-methylpropyl)-1,3-benzothiazole-6-sulfonamide (1.12 g, 1.74 mmol) in MeOH (8.7 mL) was added 4 N HCl in dioxane (5.0 mL, 20 mmol) and the reaction mixture was stirred for 5 hours. The reaction was concentrated under reduced pressure and concentrated from heptanes. The product was use as such in the next step.

Provenance & Evidence