Hydrochloric Acid → HCID 117629145, compound

HRID 2278379Notes

Reaction equation

HRID 2278379 reaction equation
[Si]([O:8][CH2:9][C@@H:10]([N:24]([CH2:37][CH:38]([CH3:40])[CH3:39])[S:25]([C:28]1[CH:36]=[CH:35][C:31]2[N:32]=[CH:33][S:34][C:30]=2[CH:29]=1)(=[O:27])=[O:26])[C:11]1[S:12][C:13]([CH2:16][NH:17]S(C(C)(C)C)=O)=[CH:14][CH:15]=1)(C(C)(C)C)(C)C.[ClH:41].O1CCOCC1>CO>[ClH:41].[NH2:17][CH2:16][C:13]1[S:12][C:11]([C@H:10]([N:24]([CH2:37][CH:38]([CH3:40])[CH3:39])[S:25]([C:28]2[CH:36]=[CH:35][C:31]3[N:32]=[CH:33][S:34][C:30]=3[CH:29]=2)(=[O:27])=[O:26])[CH2:9][OH:8])=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 131733467HCID 131733467, compound

Product 1

HCID 117629145HCID 117629145, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-(5-{[(tert-butylsulfinyl)amino]methyl}thiophen-2-yl)ethyl]-N-(2-methylpropyl)-1,3-benzothiazole-6-sulfonamide (1.12 g, 1.74 mmol) in MeOH (8.7 mL) was added 4 N HCl in dioxane (5.0 mL, 20 mmol) and the reaction mixture was stirred for 5 hours. The reaction was concentrated under reduced pressure and concentrated from heptanes. The product was use as such in the next step.

Workup

  1. concentrationThe reaction was concentrated under reduced pressure
  2. concentrationconcentrated from heptanes

Sources & evidence

ORD record
ord-d63760f207e84781be10e0a2df191ebb
Source dataset
uspto-grants-2015_09
Patent number
US09133157B2

Reaction notes

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