Hydrochloric Acid → HCID 136414660, compound

Participants

Reaction Steps

Into a 100-ml, 4-necked flask equipped with a stirrer were introduced 1.5 g (11.3 mmole) of O-ethyl-N-nitroisourea, 8 g of water, 2 g of sodium chloride and 2 g (29.6 mmole) of methylamine hydrochloride, and the resulting material was maintained at 15 degree centigrade. Thereafter, 0.1 g of sodium hydrogen carbonate was added to the mixture and the mixture was stirred at 30 degree centigrade for 15 hours. Then, while stirring the reaction mixture, 0.1 g of concentrated hydrochloric acid and 200 ml of water were added to the mixture to give a homogenious aqueous solution of O-ethyl-N-methyl-N′-nitroisourea, which was analyzed by HPLC. In the aqueous solution, 1.2 g of O-ethyl-N-methyl-N′-nitroisourea was contained, and the reaction yield was 70%.

Provenance & Evidence