Hydrochloric Acid → HCID 136414660, compound

HRID 227840Notes

Reaction equation

HRID 227840 reaction equation
[CH2:1]([O:3][C:4](=[NH:9])[NH:5][N+:6]([O-:8])=[O:7])[CH3:2].[Cl-].[Na+].Cl.CN.[C:15](=O)([O-])O.[Na+].Cl>O>[CH2:1]([O:3][C:4](=[N:5][N+:6]([O-:8])=[O:7])[NH:9][CH3:15])[CH3:2]

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 516892Sodium BicarbonateHCID 6364545Methylamine hydrochlorideHCID 136383700HCID 136383700, compound

Product 1

HCID 136414660HCID 136414660, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Into a 100-ml, 4-necked flask equipped with a stirrer were introduced 1.5 g (11.3 mmole) of O-ethyl-N-nitroisourea, 8 g of water, 2 g of sodium chloride and 2 g (29.6 mmole) of methylamine hydrochloride, and the resulting material was maintained at 15 degree centigrade. Thereafter, 0.1 g of sodium hydrogen carbonate was added to the mixture and the mixture was stirred at 30 degree centigrade for 15 hours. Then, while stirring the reaction mixture, 0.1 g of concentrated hydrochloric acid and 200 ml of water were added to the mixture to give a homogenious aqueous solution of O-ethyl-N-methyl-N′-nitroisourea, which was analyzed by HPLC. In the aqueous solution, 1.2 g of O-ethyl-N-methyl-N′-nitroisourea was contained, and the reaction yield was 70%.

Workup

  1. customInto a 100-ml, 4-necked flask equipped with a stirrer
  2. temperaturethe resulting material was maintained at 15 degree centigrade
  3. additionwere added to the mixture

Sources & evidence

ORD record
ord-67637811adc147828436699754600a44
Source dataset
uspto-grants-2009_07
Patent number
US07560593B2

Reaction notes

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