Sodium Hydroxide → HCID 57388439, compound

HRID 2278480Notes

Reaction equation

HRID 2278480 reaction equation
[OH-].[Na+:2].C[O:4][C:5](=[O:22])[CH2:6][C:7]1[N:12]=[C:11]([O:13][CH3:14])[C:10]([F:15])=[C:9]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[N:8]=1>C1COCC1>[F:15][C:10]1[C:11]([O:13][CH3:14])=[N:12][C:7]([CH2:6][C:5]([O-:22])=[O:4])=[N:8][C:9]=1[N:16]1[CH2:17][CH2:18][O:19][CH2:20][CH2:21]1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57388438HCID 57388438, compound

Product 1

HCID 57388439HCID 57388439, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

7.9 ml of 2N sodium hydroxide are added to a solution of 3.46 g of (5-fluoro-4-methoxy-6-morpholin-4-ylpyrimidin-2-yl)acetic acid methyl ester in 36 ml of THF. The reaction medium is stirred at ambient temperature for 24 hours. The reaction medium is concentrated under reduced pressure. The residue obtained is oven-dried under vacuum in the presence of P2O5 so as to give 3.7 g of sodium (5-fluoro-4-methoxy-6-morpholin-4-ylpyrimidin-2-yl)acetate, the characteristics of which are the following:

Workup

  1. concentrationThe reaction medium is concentrated under reduced pressure
  2. customThe residue obtained
  3. dry with materialis oven-dried under vacuum in the presence of P2O5 so as

Sources & evidence

ORD record
ord-ed8abd183ee4426fa210be9eb1d506af
Source dataset
uspto-grants-2015_09
Patent number
US09133168B2

Reaction notes

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