Sodium Hydroxide → Sodium (5-fluoro-1-methyl-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

HRID 2278486Notes

Reaction equation

HRID 2278486 reaction equation
[OH-].[Na+:2].C[O:4][C:5](=[O:22])[CH2:6][C:7]1[N:8]([CH3:21])[C:9](=[O:20])[C:10]([F:19])=[C:11]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[N:12]=1>C1COCC1>[F:19][C:10]1[C:9](=[O:20])[N:8]([CH3:21])[C:7]([CH2:6][C:5]([O-:22])=[O:4])=[N:12][C:11]=1[N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57388476(5-Fluoro-1-methyl-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetic acid methyl ester

Product 1

HCID 57388477Sodium (5-fluoro-1-methyl-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2 ml of 2N sodium hydroxide are added to a solution of 759 mg of (5-fluoro-1-methyl-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetic acid methyl ester in 8 ml of THF. The reaction medium is stirred at ambient temperature for 24 hours. The reaction medium is concentrated under reduced pressure. The residue obtained is oven-dried under vacuum in the presence of P2O5, so as to give 695 mg of sodium (5-fluoro-1-methyl-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate in the form of a white solid which is used as it is in the next step.

Workup

  1. concentrationThe reaction medium is concentrated under reduced pressure
  2. customThe residue obtained
  3. dry with materialis oven-dried under vacuum in the presence of P2O5

Sources & evidence

ORD record
ord-d8c050caeb2947388ca0d8e201ee2122
Source dataset
uspto-grants-2015_09
Patent number
US09133168B2

Reaction notes

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