1,4-Dioxane → HCID 136069588, compound

HRID 2278505Notes

Reaction equation

HRID 2278505 reaction equation
[CH3:1][O:2][C:3](=[O:20])[CH2:4][C:5]1[N:10]=[C:9]([O:11]C)[C:8]([Cl:13])=[C:7]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:6]=1.O1CCOCC1>C(OCC)C>[CH3:1][O:2][C:3](=[O:20])[CH2:4][C:5]1[NH:10][C:9](=[O:11])[C:8]([Cl:13])=[C:7]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:6]=1

Participants

4

Reactant 2

HCID 312751,4-DioxaneHCID 57388479HCID 57388479, compound

Product 1

HCID 136069588HCID 136069588, compoundYield 86.8%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

500 mg of (5-chloro-4-methoxy-6-morpholin-4-ylpyrimidin-2-yl)acetic acid methyl ester and 5 ml of 4N hydrochloric dioxane are placed in a microwave tube. After microwave irradiation for 30 minutes at a temperature of 110° C., the reaction medium is concentrated under reduced pressure. The residue obtained is taken up in ethyl ether. The solid formed is filtered off so as to give 414 mg of (5-chloro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetic acid methyl ester, the characteristics of which are the following:

Workup

  1. customAfter microwave irradiation for 30 minutes at a temperature of 110° C.
  2. concentrationthe reaction medium is concentrated under reduced pressure
  3. customThe residue obtained
  4. customThe solid formed
  5. filtrationis filtered off so as

Sources & evidence

ORD record
ord-c6b82e63739741bc9dc7be743681fade
Source dataset
uspto-grants-2015_09
Patent number
US09133168B2

Reaction notes

Loading…