1,4-Dioxane → HCID 136069588, compound

Participants

Reaction Steps

500 mg of (5-chloro-4-methoxy-6-morpholin-4-ylpyrimidin-2-yl)acetic acid methyl ester and 5 ml of 4N hydrochloric dioxane are placed in a microwave tube. After microwave irradiation for 30 minutes at a temperature of 110° C., the reaction medium is concentrated under reduced pressure. The residue obtained is taken up in ethyl ether. The solid formed is filtered off so as to give 414 mg of (5-chloro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetic acid methyl ester, the characteristics of which are the following:

Provenance & Evidence