Sodium Hydroxide → HCID 136069589, compound

HRID 2278506Notes

Reaction equation

HRID 2278506 reaction equation
[OH-].[Na+:2].C[O:4][C:5](=[O:21])[CH2:6][C:7]1[NH:8][C:9](=[O:20])[C:10]([Cl:19])=[C:11]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[N:12]=1>C1COCC1>[Cl:19][C:10]1[C:9](=[O:20])[NH:8][C:7]([CH2:6][C:5]([O-:21])=[O:4])=[N:12][C:11]=1[N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 136069588HCID 136069588, compound

Product 1

HCID 136069589HCID 136069589, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.4 ml of 2N sodium hydroxide are added to a solution of 410 mg of (5-chloro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetic acid methyl ester in 3.6 ml of THF. The reaction medium is stirred at ambient temperature for 24 hours. The reaction medium is concentrated under reduced pressure. The residue obtained is oven-dried under vacuum in the presence of P2O5, so as to give 400 mg of sodium (5-chloro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate, the characteristics of which are the following:

Workup

  1. concentrationThe reaction medium is concentrated under reduced pressure
  2. customThe residue obtained
  3. dry with materialis oven-dried under vacuum in the presence of P2O5

Sources & evidence

ORD record
ord-06c6d63b02ca48b692ece2f4c43c769b
Source dataset
uspto-grants-2015_09
Patent number
US09133168B2

Reaction notes

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