Sodium Hydroxide → HCID 136069589, compound

HRID 2278508Notes

Reaction equation

HRID 2278508 reaction equation
[OH-].[Na+:2].C([O:5][C:6](=[O:22])[CH2:7][C:8]1[NH:9][C:10](=[O:21])[C:11]([Cl:20])=[C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:13]=1)C>C1COCC1>[Cl:20][C:11]1[C:10](=[O:21])[NH:9][C:8]([CH2:7][C:6]([O-:22])=[O:5])=[N:13][C:12]=1[N:14]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 136069591HCID 136069591, compound

Product 1

HCID 136069589HCID 136069589, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2.8 ml of 2N sodium hydroxide are added to a solution of 800 mg of (5-chloro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetic acid ethyl ester in 7.2 ml of THF. The reaction medium is stirred at ambient temperature for 24 hours. The reaction medium is concentrated under reduced pressure. The residue obtained is oven-dried under vacuum in the presence of P2O5, so as to give 750 mg of sodium (5-chloro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate, the characteristics of which are the following:

Workup

  1. concentrationThe reaction medium is concentrated under reduced pressure
  2. customThe residue obtained
  3. dry with materialis oven-dried under vacuum in the presence of P2O5

Sources & evidence

ORD record
ord-e6959917183d497cb1e591d2d13943ed
Source dataset
uspto-grants-2015_09
Patent number
US09133168B2

Reaction notes

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