Sodium → 2-[2-(4-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-(2-fluoromethylmorpholin-4-yl)-3H-pyrimidin-4-one

HRID 2278529Notes

Reaction equation

HRID 2278529 reaction equation
[Na].[F:2][CH2:3][CH:4]1[O:9][CH2:8][CH2:7][N:6]([C:10]2[N:11]=[C:12]([CH2:17][C:18]([OH:20])=O)[NH:13][C:14](=[O:16])[CH:15]=2)[CH2:5]1.[F:21][C:22]1[CH:30]=[CH:29][CH:28]=[C:27]2[C:23]=1[CH2:24][CH2:25][NH:26]2>>[F:21][C:22]1[CH:30]=[CH:29][CH:28]=[C:27]2[C:23]=1[CH2:24][CH2:25][N:26]2[C:18](=[O:20])[CH2:17][C:12]1[NH:13][C:14](=[O:16])[CH:15]=[C:10]([N:6]2[CH2:7][CH2:8][O:9][CH:4]([CH2:3][F:2])[CH2:5]2)[N:11]=1

Participants

4

Reactant 3

HCID 5360545SodiumHCID 162444404-Fluoro-2,3-dihydro-1H-indoleHCID 136378673[4-(2-Fluoromethylmorpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetic acid

Product 1

HCID 1360984692-[2-(4-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-(2-fluoromethylmorpholin-4-yl)-3H-pyrimidin-4-one

Procedure

The product is prepared by following the procedure described in step 3b of example 1b, but using 670 mg of the sodium salt of [4-(2-fluoromethylmorpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetic acid and 345 mg of 4-fluoro-2,3-dihydro-1H-indole. 161 mg of 2-[2-(4-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-(2-fluoromethylmorpholin-4-yl)-3H-pyrimidin-4-one are obtained in the form of a white solid, the characteristics of which are the following:

Workup

  1. customThe product is prepared

Sources & evidence

ORD record
ord-5708e6d589044b3eb95964daa3c91518
Source dataset
uspto-grants-2015_09
Patent number
US09133168B2

Reaction notes

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