反应详情

温度

130 °C

In a microwave tube, 0.45 g of 2-ethylmorpholine is placed in 10 ml of ethanol, 2.11 ml of N,N-diisopropylethylamine and 2.29 g of ethyl 3-ethoxy-3-iminopropanoate hydrochloride. The tube is then microwave-heated at 130° C. for 1 hour and then allowed to return to ambient temperature. The reaction mixture is concentrated under reduced pressure. After purification by silica column chromatography, eluent: 90/05 dichloromethane/methanol, 550 mg of [4-(2-ethylmorpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetic acid ethyl ester are obtained in the form of a beige powder, the characteristics of which are the following:

1. customto return to ambient temperature
2. concentrationThe reaction mixture is concentrated under reduced pressure
3. customAfter purification by silica column chromatography, eluent