Sodium Hydroxide → Sodium (4-methoxy-6-morpholin-4-ylpyrimidin-2-yl)acetate

Participants

Reaction Steps

8.8 ml of 1N sodium hydroxide are added to a solution of 2.5 g of (4-methoxy-6-morpholin-4-ylpyrimidin-2-yl)acetic acid ethyl ester in 15 ml of THF. The reaction medium is stirred at ambient temperature for 48 hours and then concentrated under reduced pressure. After oven-drying under vacuum, 2.4 g of sodium (4-methoxy-6-morpholin-4-yl-pyrimidin-2-yl)acetate are obtained, which will be used as it is in the next step.

Provenance & Evidence