Sodium Hydroxide → Sodium (4-methoxy-6-morpholin-4-ylpyrimidin-2-yl)acetate

HRID 2278583Notes

Reaction equation

HRID 2278583 reaction equation
[OH-].[Na+:2].C([O:5][C:6](=[O:22])[CH2:7][C:8]1[N:13]=[C:12]([O:14][CH3:15])[CH:11]=[C:10]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[N:9]=1)C>C1COCC1>[CH3:15][O:14][C:12]1[CH:11]=[C:10]([N:16]2[CH2:17][CH2:18][O:19][CH2:20][CH2:21]2)[N:9]=[C:8]([CH2:7][C:6]([O-:22])=[O:5])[N:13]=1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86699276(4-Methoxy-6-morpholin-4-ylpyrimidin-2-yl)acetic acid ethyl ester

Product 1

HCID 86699277Sodium (4-methoxy-6-morpholin-4-ylpyrimidin-2-yl)acetate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

8.8 ml of 1N sodium hydroxide are added to a solution of 2.5 g of (4-methoxy-6-morpholin-4-ylpyrimidin-2-yl)acetic acid ethyl ester in 15 ml of THF. The reaction medium is stirred at ambient temperature for 48 hours and then concentrated under reduced pressure. After oven-drying under vacuum, 2.4 g of sodium (4-methoxy-6-morpholin-4-yl-pyrimidin-2-yl)acetate are obtained, which will be used as it is in the next step.

Workup

  1. concentrationconcentrated under reduced pressure
  2. dry with materialAfter oven-drying under vacuum, 2.4 g of sodium (4-methoxy-6-morpholin-4-yl-pyrimidin-2-yl)acetate
  3. customare obtained

Sources & evidence

ORD record
ord-9f496fe5e5094a4589d33e224e5c9ba1
Source dataset
uspto-grants-2015_09
Patent number
US09133168B2

Reaction notes

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