Water → HCID 68281659, compound

HRID 2278591Notes

Reaction equation

HRID 2278591 reaction equation
C(N(CC)CC)C.[C:8](Cl)(=[O:10])[CH3:9].[Br:12][C:13]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:14]=1[NH2:15].O>ClCCl>[Br:12][C:13]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:14]=1[NH:15][C:8](=[O:10])[CH3:9]

Participants

6

Reactant 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 147700052-Bromo-3-fluoroaniline

Product 1

HCID 68281659HCID 68281659, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

2.7 ml of triethylamine and then 1.2 ml of acetyl chloride are added to a solution of 3 g of 2-bromo-3-fluoroaniline in 30 ml of dichloromethane. The reaction mixture is stirred for 72 hours and then treated with a mixture of water and dichloromethane. The phases are separated and the organic phase is concentrated so as to give 3.75 g of N-(2-bromo-3-fluorophenyl)acetamide.

Workup

  1. customThe phases are separated
  2. concentrationthe organic phase is concentrated so as

Sources & evidence

ORD record
ord-4efb01aaf7fe4d1ca66fe38e0ea0f28d
Source dataset
uspto-grants-2015_09
Patent number
US09133168B2

Reaction notes

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