1'-Methylspiro[indoline-3,4'-piperidine] → HCID 136128233, compound

HRID 2278621Notes

Reaction equation

HRID 2278621 reaction equation
[N:1]1([C:7]2[N:8]=[C:9](CC([O-])=O)[NH:10][C:11](=[O:13])[CH:12]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Na+].CN1CCC2(C3C(=CC=CC=3)NC2)CC1>>[N:1]1([C:7]2[N:8]=[CH:9][NH:10][C:11](=[O:13])[CH:12]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 128015871'-Methylspiro[indoline-3,4'-piperidine]HCID 136041844Sodium (4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

Product 1

HCID 136128233HCID 136128233, compound

Procedure

The product is prepared by following the procedure described in example 10d using 35.5 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate (example 1d, step 2d) and 25 mg of 1′-methylspiro[indoline-3,4′-piperidine] in place of 4-pyridin-4-yl-2,3-dihydro-1H-indole. 13.8 mg of 212-r-methylspiro[indole-3,4′-piperidin]-1(2H)-yl)-2-oxoethyl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one are obtained in the form of a pale pink powder, the characteristics of which are the following:

Workup

  1. customThe product is prepared

Sources & evidence

ORD record
ord-1c2049b4836d44d09d6dbc2fab682c51
Source dataset
uspto-grants-2015_09
Patent number
US09133168B2

Reaction notes

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