反应详情

An oven dried resealable Schlenk tube was evacuated and backfilled with argon and charged with palladium acetate (2.2 mg, 0.01 mmol, 1.0 mol %), 2-(di-tert-butylphosphino)biphenyl (4.5 mg, 0.015 mmol, 1.5 mol %), phenylboron dihydroxide (183 mg, 1.5 mmol), additive (3.0 mmol), and 4-chlorotoluene (0.12 mL, 1.0 mmol). The tube was evacuated and backfilled with argon, and THF (2 mL) was added through a rubber septum. The reaction mixture was stirred at room temperature for 20 hours. The reaction mixture was then diluted with ethyl acetate (30 mL) and poured into a separatory funnel. The mixture was washed with 2.0M NaOH (20 mL), followed by brine (20 mL). The organic layer was submitted for GC analysis giving the results tabulated below.

1. customAn oven dried resealable Schlenk tube
2. customwas evacuated
3. customThe tube was evacuated
4. additionwas added through a rubber septum
5. additionThe reaction mixture was then diluted with ethyl acetate (30 mL)
6. additionpoured into a separatory funnel
7. washThe mixture was washed with 2.0M NaOH (20 mL)
8. customgiving the results