Sodium Hydroxide → HCID 178525241, compound

HRID 2278669Notes

Reaction equation

HRID 2278669 reaction equation
[OH-].[Na+:2].C([O:5][C:6](=[O:21])[CH2:7][C:8]1[NH:9][C:10](=[S:20])[CH:11]=[C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:13]=1)C>C1COCC1>[N:14]1([C:12]2[N:13]=[C:8]([CH2:7][C:6]([O-:21])=[O:5])[NH:9][C:10](=[S:20])[CH:11]=2)[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178470781HCID 178470781, compound

Product 1

HCID 178525241HCID 178525241, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3.05 ml of 2N sodium hydroxide are added to a solution of 865 mg of (4-morpholin-4-yl-6-thioxo-1,6-dihydropyrimidin-2-yl)acetic acid ethyl ester in 15 ml of THF. The reaction medium is stirred at ambient temperature for 24 hours. The reaction medium is concentrated under reduced pressure. The residue obtained is oven-dried under vacuum in the presence of P2O5, so as to give 0.8 g of sodium (4-morpholin-4-yl-6-thioxo-1,6-dihydropyrimidin-2-yl)acetate, the characteristics of which are the following:

Workup

  1. concentrationThe reaction medium is concentrated under reduced pressure
  2. customThe residue obtained
  3. dry with materialis oven-dried under vacuum in the presence of P2O5

Sources & evidence

ORD record
ord-281297fd19c04b72b10757be51697e56
Source dataset
uspto-grants-2015_09
Patent number
US09133168B2

Reaction notes

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