Sodium Hydroxide → Sodium (5-fluoro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

HRID 2278678Notes

Reaction equation

HRID 2278678 reaction equation
[OH-].[Na+:2].C[O:4][C:5](=[O:21])[CH2:6][C:7]1[NH:8][C:9](=[O:20])[C:10]([F:19])=[C:11]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[N:12]=1>C1COCC1>[F:19][C:10]1[C:9](=[O:20])[NH:8][C:7]([CH2:6][C:5]([O-:21])=[O:4])=[N:12][C:11]=1[N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 136069584(5-Fluoro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetic acid methyl ester

Product 1

HCID 136069585Sodium (5-fluoro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.43 ml of 2N sodium hydroxide is added to a solution of 116 mg of (5-fluoro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetic acid methyl ester in 1.2 ml of THF. The reaction medium is stirred at ambient temperature for 24 hours. The reaction medium is concentrated under reduced pressure. The residue obtained is oven-dried under vacuum in the presence of P2O5, so as to give 110 mg of sodium (5-fluoro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate, the characteristics of which are the following:

Workup

  1. concentrationThe reaction medium is concentrated under reduced pressure
  2. customThe residue obtained
  3. dry with materialis oven-dried under vacuum in the presence of P2O5

Sources & evidence

ORD record
ord-179b1c23254c406da292ff3bbe326527
Source dataset
uspto-grants-2015_09
Patent number
US09133168B2

Reaction notes

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