Sodium Hydroxide → HCID 178525242, compound

Participants

Reaction Steps

0.85 ml of 2N sodium hydroxide is added to a solution of 255 mg of (5-fluoro-4-morpholin-4-yl-6-thioxo-1,6-dihydropyrimidin-2-yl)acetic acid ethyl ester in 2 ml of THF. The reaction medium is stirred at ambient temperature for 24 hours. The reaction medium is concentrated under reduced pressure. The residue obtained is oven-dried under vacuum in the presence of P2O5, so as to give 0.32 g of sodium (5-fluoro-4-morpholin-4-yl-6-thioxo-1,6-dihydropyrimidin-2-yl)acetate which is used as it is in the next step.

Provenance & Evidence