Sodium Hydroxide → HCID 178525242, compound

HRID 2278679Notes

Reaction equation

HRID 2278679 reaction equation
[OH-].[Na+:2].C([O:5][C:6](=[O:22])[CH2:7][C:8]1[NH:9][C:10](=[S:21])[C:11]([F:20])=[C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:13]=1)C>C1COCC1>[F:20][C:11]1[C:10](=[S:21])[NH:9][C:8]([CH2:7][C:6]([O-:22])=[O:5])=[N:13][C:12]=1[N:14]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178470782HCID 178470782, compound

Product 1

HCID 178525242HCID 178525242, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.85 ml of 2N sodium hydroxide is added to a solution of 255 mg of (5-fluoro-4-morpholin-4-yl-6-thioxo-1,6-dihydropyrimidin-2-yl)acetic acid ethyl ester in 2 ml of THF. The reaction medium is stirred at ambient temperature for 24 hours. The reaction medium is concentrated under reduced pressure. The residue obtained is oven-dried under vacuum in the presence of P2O5, so as to give 0.32 g of sodium (5-fluoro-4-morpholin-4-yl-6-thioxo-1,6-dihydropyrimidin-2-yl)acetate which is used as it is in the next step.

Workup

  1. concentrationThe reaction medium is concentrated under reduced pressure
  2. customThe residue obtained
  3. dry with materialis oven-dried under vacuum in the presence of P2O5

Sources & evidence

ORD record
ord-20a6243860d8498e995033d11882e611
Source dataset
uspto-grants-2015_09
Patent number
US09133168B2

Reaction notes

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