Ammonia → HCID 70558665, compound

HRID 2278792Notes

Reaction equation

HRID 2278792 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][O:9][C:10]1[C:15]([CH3:16])=[CH:14][C:13]([C:17]2[N:21]=[C:20]([C:22]3[CH:27]=[C:26]([O:28][CH3:29])[N:25]=[C:24]([CH:30]4[CH2:34][CH2:33][CH2:32][CH2:31]4)[CH:23]=3)[O:19][N:18]=2)=[CH:12][C:11]=1[CH2:35][CH3:36])(=O)=O.[NH3:37]>CO>[CH:30]1([C:24]2[CH:23]=[C:22]([C:20]3[O:19][N:18]=[C:17]([C:13]4[CH:14]=[C:15]([CH3:16])[C:10]([O:9][CH2:8][CH2:7][CH2:6][NH2:37])=[C:11]([CH2:35][CH3:36])[CH:12]=4)[N:21]=3)[CH:27]=[C:26]([O:28][CH3:29])[N:25]=2)[CH2:34][CH2:33][CH2:32][CH2:31]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86702021HCID 86702021, compound

Product 1

HCID 70558665HCID 70558665, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)propyl methanesulfonate (1.30 g, 2.52 mmol) in 7 N NH3 in methanol (30 mL) is stirred at 55° C. for 24 h. The mixture is concentrated and dried to give crude 3-(4-(5-(2-cyclopentyl-6-methoxypyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)propan-1-amine (1.24 g) as a pale yellow foam; LC-MS: tR=0.95 min, [M+H]+=437.33.

Workup

  1. concentrationThe mixture is concentrated
  2. customdried

Sources & evidence

ORD record
ord-cefa183df01d4df682cd80cc5b485a8a
Source dataset
uspto-grants-2015_09
Patent number
US09133179B2

Reaction notes

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