HCID 66671444, compound → HCID 66671682, compound

HRID 2278868Notes

Reaction equation

HRID 2278868 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([C:11]#[C:12][CH2:13][CH2:14][OH:15])[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH3:16].[H][H]>C(O)C.[Pd]>[NH2:1][C:2]1[N:10]=[C:9]([CH2:11][CH2:12][CH2:13][CH2:14][OH:15])[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH3:16]

Participants

5

Reactant 2

HCID 66671444HCID 66671444, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 66671682HCID 66671682, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 4-(6-amino-9-methyl-9H-purin-2-yl)-but-3-yn-1-ol (1.5 g, 6.88 mmol) in ethanol (30 ml) was added palladium 10% on graphite (1.35 g, 20% in weight). The mixture was stirred for 16 h in autoclave at 50° C. under 4 atm of hydrogen. The catalyst was filtered through a small pad of Celite and the solution obtained was evaporated under reduced pressure, to give a residue that was used for the following reaction without further purification.

Workup

  1. filtrationThe catalyst was filtered through a small pad of Celite
  2. customthe solution obtained
  3. customwas evaporated under reduced pressure
  4. customto give a residue that
  5. customwas used for the following reaction without further purification

Sources & evidence

ORD record
ord-8147922cb55448d4a2d376090e7f587a
Source dataset
uspto-grants-2015_09
Patent number
US09133197B2

Reaction notes

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