HCID 66671444, compound → HCID 66671682, compound

Participants

Reaction Steps

To a solution of 4-(6-amino-9-methyl-9H-purin-2-yl)-but-3-yn-1-ol (1.5 g, 6.88 mmol) in ethanol (30 ml) was added palladium 10% on graphite (1.35 g, 20% in weight). The mixture was stirred for 16 h in autoclave at 50° C. under 4 atm of hydrogen. The catalyst was filtered through a small pad of Celite and the solution obtained was evaporated under reduced pressure, to give a residue that was used for the following reaction without further purification.

Provenance & Evidence