HCID 46912313, compound → HCID 46912316, compound

HRID 2278880Notes

Reaction equation

HRID 2278880 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([CH:11]([OH:15])[CH2:12][CH2:13][CH3:14])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([N:17]1[N:21]=[CH:20][CH:19]=[N:18]1)[N:6]2[CH3:16]>C(Cl)Cl.O=[Mn]=O>[NH2:1][C:2]1[N:10]=[C:9]([C:11](=[O:15])[CH2:12][CH2:13][CH3:14])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([N:17]1[N:21]=[CH:20][CH:19]=[N:18]1)[N:6]2[CH3:16]

Participants

4

Reactant 1

HCID 46912313HCID 46912313, compound

Product 1

HCID 46912316HCID 46912316, compoundYield 40%

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

MnO2 (439 mg, 5.04 mmol) was added to a solution of 1-(6-amino-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-2-yl)butan-1-ol (51 mg, 0.2 mmol) in DCM (4 ml) at RT. The resulting heterogeneous solution was stirred overnight. After filtration over a celite pad, the solvent was removed under reduced pressure to afford the desired product as a white powder.

Workup

  1. filtrationAfter filtration over a celite pad
  2. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-58e9b14bd777454bb02dc512d26441ff
Source dataset
uspto-grants-2015_09
Patent number
US09133197B2

Reaction notes

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