反应详情

A suspension of Example A8 (1.3 g, 4.65 mmol) and NH4Cl (7.5 g, 140 mmol) in MeOH (24 mL) and THF (24 mL) was treated portion-wise with zinc dust (3 g, 45.9 mmol) and stirred at RT overnight. The solids were removed via filtration through diatomaceous earth and the filtrate concentrated to dryness to afford 5-((2-chloropyridin-4-yl)oxy)-6-ethylpyridin-2-amine (1.1 g, 85%). MS (ESI) m/z: 250.1 (M+H+).

1. customThe solids were removed via filtration through diatomaceous earth
2. concentrationthe filtrate concentrated to dryness