反应详情

A mixture of 4-(2-bromo-5-fluoro-4-nitrophenoxy)-2-chloropyridine (1.16 g, 3.34 mmol) and Raney Ni (0.5 g) in EtOH (40 mL) was hydrogenated (1 atm) overnight, the solids removed via filtration and washed with EtOH. The filtrate was concentrated to dryness, the residue dissolved in EtOAc, washed with brine, dried over Na2SO4 and concentrated to dryness to afford 5-bromo-4-((2-chloropyridin-4-yl)oxy)-2-fluoroaniline (994 mg, 94%). MS (ESI) m/z: (M+H+): 318.9.

1. custom(1 atm) overnight
2. customthe solids removed via filtration
3. washwashed with EtOH
4. concentrationThe filtrate was concentrated to dryness
5. dissolutionthe residue dissolved in EtOAc
6. washwashed with brine
7. dry with materialdried over Na2SO4
8. concentrationconcentrated to dryness