HCID 90426656, compound → HCID 90427659, compound

Participants

Reaction Steps

A mixture of 4-(2-bromo-5-fluoro-4-nitrophenoxy)-2-chloropyridine (1.16 g, 3.34 mmol) and Raney Ni (0.5 g) in EtOH (40 mL) was hydrogenated (1 atm) overnight, the solids removed via filtration and washed with EtOH. The filtrate was concentrated to dryness, the residue dissolved in EtOAc, washed with brine, dried over Na2SO4 and concentrated to dryness to afford 5-bromo-4-((2-chloropyridin-4-yl)oxy)-2-fluoroaniline (994 mg, 94%). MS (ESI) m/z: (M+H+): 318.9.

Provenance & Evidence