反应详情

温度

0 °C

410 mg of (4-benzyl-2,2-dimethyl-piperazin-1-yl)-[6-(4-benzyloxy-2-fluoro-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-methanone were dissolved in 8 ml of THF. Under Argon-atmosphere, 0.53 ml of lithium aluminium hydride (2.4M in THF) was added and the reaction was heated to reflux for 2 h. The reaction was then cooled to 0° C., and quenched by the addition of 3 ml EtOAc and 3 ml water. The mixture was filtered over celite by suction and washed with EtOAc. The solvents were removed in vacuo and 200 mg (50%) of the title compound were obtained and used without further purification.

1. temperaturethe reaction was heated
2. temperatureto reflux for 2 h
3. customquenched by the addition of 3 ml EtOAc and 3 ml water
4. filtrationThe mixture was filtered over celite by suction
5. washwashed with EtOAc
6. customThe solvents were removed in vacuo