Hydrochloric Acid → HCID 178434414, compound

Participants

Reaction Steps

130 mg 4-[4-(2,2-dimethyl-piperazin-1-ylmethyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-3-fluoro-phenol were dissolved in 5 ml dry tetrahydrofurane and 1 ml HCl (4N in 1,4-dioxane) was added. After stirring the reaction at r.t. for 60 min the volatiles were removed in vacuo and the resulting residue was purified by flash chromatography (silica, heptane/ethyl acetate/methanol gradient). 60 mg (23%) of the title compound were obtained.

Provenance & Evidence