反应详情

130 mg 4-[4-(2,2-dimethyl-piperazin-1-ylmethyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-3-fluoro-phenol were dissolved in 5 ml dry tetrahydrofurane and 1 ml HCl (4N in 1,4-dioxane) was added. After stirring the reaction at r.t. for 60 min the volatiles were removed in vacuo and the resulting residue was purified by flash chromatography (silica, heptane/ethyl acetate/methanol gradient). 60 mg (23%) of the title compound were obtained.

1. customthe reaction at r.t. for 60 min the volatiles
2. customwere removed in vacuo
3. customthe resulting residue was purified by flash chromatography (silica, heptane/ethyl acetate/methanol gradient)