Diisopropylethylamine → HCID 118059329, compound

HRID 2279096Notes

Reaction equation

HRID 2279096 reaction equation
[Na+].[CH3:2][C:3]1[C:11]2[C:10]([C:12]([O-:14])=O)=[CH:9][C:8]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH:22]4[CH2:27][CH2:26][CH2:25][CH2:24][O:23]4)=[CH:17][CH:16]=3)=[N:7][C:6]=2[N:5]([CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][O:29]2)[N:4]=1.CCN(C(C)C)C(C)C.[C:43]([O:47][C:48]([N:50]1[CH2:57][C:54]2([CH2:56][CH2:55]2)[NH:53][CH2:52][CH2:51]1)=[O:49])([CH3:46])([CH3:45])[CH3:44]>C(Cl)Cl.O>[C:43]([O:47][C:48]([N:50]1[CH2:57][C:54]2([CH2:55][CH2:56]2)[N:53]([C:12]([C:10]2[C:11]3[C:3]([CH3:2])=[N:4][N:5]([CH:28]4[CH2:33][CH2:32][CH2:31][CH2:30][O:29]4)[C:6]=3[N:7]=[C:8]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH:22]4[CH2:27][CH2:26][CH2:25][CH2:24][O:23]4)=[CH:17][CH:16]=3)[CH:9]=2)=[O:14])[CH2:52][CH2:51]1)=[O:49])([CH3:46])([CH3:44])[CH3:45]

Participants

6

Reactant 3

HCID 81531DiisopropylethylamineHCID 46942212tert-Butyl 4,7-diazaspiro[2.5]octane-7-carboxylateHCID 118059371HCID 118059371, compound

Product 1

HCID 118059329HCID 118059329, compoundYield 67.9%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent2×

Procedure

To a suspension of 300 mg of 3-methyl-1-(tetrahydro-pyran-2-yl)-6-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid sodium salt in 7.5 ml of DCM were added 0.12 ml of Hünig's base, 376 mg of BEP and 146 mg of 4,7-diaza-spiro[2.5]octane-7-carboxylic acid tert-butyl ester. The reaction was stirred overnight at r.t. For workup it was diluted with water and DCM and the layers were separated. The organic layer was washed with water twice, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash chromatography (silica, heptane/EtOAc gradient) to obtain 280 mg (66%) of the title compound.

Workup

  1. customthe layers were separated
  2. washThe organic layer was washed with water twice
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customThe residue was purified by flash chromatography (silica, heptane/EtOAc gradient)

Sources & evidence

ORD record
ord-5f6a679ab82149ab902413ff5a270a51
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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