HCID 136623205, compound → HCID 178434392, compound

Participants

Reaction Steps

160 mg 4-[6-(4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-4,7-diaza-spiro[2.5]octane-7-carboxylic acid tert-butyl ester were dissolved in 6 ml HCl (4N in 1,4-dioxane). After stirring the reaction at r.t. for 15 min the precipitated residue was isolated by filtration and washed with 1,4-dioxane and THF. It was taken up in water and freeze dried in vacuo. 115 mg (100%) of the title compound were obtained.

Provenance & Evidence