HCID 136623205, compound → HCID 178434392, compound

HRID 2279098Notes

Reaction equation

HRID 2279098 reaction equation
C(OC([N:8]1[CH2:15][C:12]2([CH2:14][CH2:13]2)[N:11]([CH2:16][C:17]2[CH:22]=[C:21]([C:23]3[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=3)[N:20]=[C:19]3[N:30](C4CCCCO4)[N:31]=[C:32]([CH3:33])[C:18]=23)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl>[CH2:13]1[C:12]2([CH2:15][NH:8][CH2:9][CH2:10][N:11]2[CH2:16][C:17]2[CH:22]=[C:21]([C:23]3[CH:24]=[CH:25][C:26]([OH:29])=[CH:27][CH:28]=3)[N:20]=[C:19]3[NH:30][N:31]=[C:32]([CH3:33])[C:18]=23)[CH2:14]1

Participants

3

Reactant 1

HCID 136623205HCID 136623205, compound

Product 1

HCID 178434392HCID 178434392, compoundYield 109.8%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

160 mg 4-[6-(4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-4,7-diaza-spiro[2.5]octane-7-carboxylic acid tert-butyl ester were dissolved in 6 ml HCl (4N in 1,4-dioxane). After stirring the reaction at r.t. for 15 min the precipitated residue was isolated by filtration and washed with 1,4-dioxane and THF. It was taken up in water and freeze dried in vacuo. 115 mg (100%) of the title compound were obtained.

Workup

  1. customthe reaction at r.t. for 15 min the precipitated residue
  2. customwas isolated by filtration
  3. washwashed with 1,4-dioxane and THF
  4. customfreeze dried in vacuo

Sources & evidence

ORD record
ord-2670e1d470bd438993a85248e38bd22c
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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