Hydrochloric Acid → HCID 178434415, compound

Participants

Reaction Steps

274 mg of 4-[6-(2-Fluoro-4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester were dissolved in 5 ml of dichloromethane, and 1 m of hydrochloric acid (4N in 1,4-dioxane) was added. After stirring at r.t. for 16 h the volatiles were removed in vacuo and the resulting residue was purified by HPLC to obtain 12 mg (7%) of the title compound.

Provenance & Evidence