Hydrochloric Acid → HCID 178434415, compound

HRID 2279115Notes

Reaction equation

HRID 2279115 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][C:22]=3[F:28])[N:18]=[C:17]3[N:29](C4CCCCO4)[N:30]=[C:31]([CH3:32])[C:16]=23)[CH2:10][C:9]1([CH3:40])[CH3:39])=O)(C)(C)C.Cl>ClCCl>[CH3:39][C:9]1([CH3:40])[NH:8][CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][C:22]=3[F:28])[N:18]=[C:17]3[NH:29][N:30]=[C:31]([CH3:32])[C:16]=23)[CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136623234HCID 136623234, compound

Product 1

HCID 178434415HCID 178434415, compoundYield 7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

274 mg of 4-[6-(2-Fluoro-4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester were dissolved in 5 ml of dichloromethane, and 1 m of hydrochloric acid (4N in 1,4-dioxane) was added. After stirring at r.t. for 16 h the volatiles were removed in vacuo and the resulting residue was purified by HPLC to obtain 12 mg (7%) of the title compound.

Workup

  1. customwere removed in vacuo
  2. customthe resulting residue was purified by HPLC

Sources & evidence

ORD record
ord-d23666eb5d2a4399859b586cdd35b2c6
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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