HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2279121Generated: October 30, 2026
Hydrochloric Acid → HCID 178436766, compound
https://huagongshe.com/reaction/2279121
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Ethyl-4-[6-(4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-2,5,5-trimethyl-piperazine-1-carboxylic acid tert-butyl ester | HCID 136623219 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178436766 | HCID 178436766 | 61.8% |
Reaction Steps
19 mg of 2-ethyl-4-[6-(4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-2,5,5-trimethyl-piperazine-1-carboxylic acid tert-butyl ester were dissolved in 0.4 ml of THF and treated with 1.5 ml of hydrochloric acid (4M in dry dioxane). After stirring at rt overnight and at 40° C. for 2 h the volatiles were removed in vacuo. The residue was triturated with dioxane and the resulting solid was isolated by suction. 8 mg (57%) of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09133181B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-8c54dec5c7644dbdb46ba62eb7eb7dea |
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| Source note | uspto-grants-2015_09 |
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