Hydrochloric Acid → HCID 178434390, compound

HRID 2279129Notes

Reaction equation

HRID 2279129 reaction equation
COC[O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:16]=[C:15]3[N:17](C4CCCCO4)[N:18]=[C:19]([CH3:20])[C:14]3=[C:13]([CH2:27][N:28]3[CH2:33][CH:32]([CH3:34])[N:31]([CH2:35][C:36]4[CH:37]=[N:38][CH:39]=[CH:40][CH:41]=4)[CH2:30][C:29]3([CH3:43])[CH3:42])[CH:12]=2)=[CH:7][CH:6]=1.Cl>O1CCOCC1>[CH3:20][C:19]1[C:14]2[C:15](=[N:16][C:11]([C:8]3[CH:7]=[CH:6][C:5]([OH:4])=[CH:10][CH:9]=3)=[CH:12][C:13]=2[CH2:27][N:28]2[CH2:33][CH:32]([CH3:34])[N:31]([CH2:35][C:36]3[CH:37]=[N:38][CH:39]=[CH:40][CH:41]=3)[CH2:30][C:29]2([CH3:43])[CH3:42])[NH:17][N:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 900135336-(4-Methoxymethoxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-4-(2,2,5-trimethyl-4-pyridin-3-ylmethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridine

Product 1

HCID 178434390HCID 178434390, compoundYield 128.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

65 mg of 6-(4-Methoxymethoxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-4-(2,2,5-trimethyl-4-pyridin-3-ylmethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridine were dissolved in 1.5 ml of 1,4-dioxane and treated with 1.5 ml of hydrochloric acid (4 M in dry dioxane). After standing at rt for 10 min the volatiles were removed in vacuo. The residue purified by HPLC and 65 mg of the title compound were obtained.

Workup

  1. customthe volatiles were removed in vacuo
  2. customThe residue purified by HPLC

Sources & evidence

ORD record
ord-78fc62e70ed644089c77393bfb0261f0
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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