Methyl bromoacetate → HCID 90013949, compound

HRID 2279148Notes

Reaction equation

HRID 2279148 reaction equation
[CH3:1][O:2][C:3](=[O:34])[CH2:4]N1CC(C)(C)N(CC2C=C(C3C=CC(O)=CC=3F)N=C3NN=C(C)C=23)CC1(C)C.[CH3:35][O:36][CH2:37][O:38][C:39]1[CH:44]=[CH:43][C:42]([C:45]2[N:50]=[C:49]3[N:51]([CH:55]4[CH2:60][CH2:59][CH2:58][CH2:57][O:56]4)[N:52]=[C:53]([CH3:54])[C:48]3=[C:47]([CH2:61][N:62]3[CH2:67][C:66]([CH3:69])([CH3:68])[NH:65][CH2:64][C:63]3([CH3:71])[CH3:70])[CH:46]=2)=[CH:41][CH:40]=1.BrCC(OC)=O>>[CH3:1][O:2][C:3](=[O:34])[CH2:4][N:65]1[CH2:64][C:63]([CH3:71])([CH3:70])[N:62]([CH2:61][C:47]2[CH:46]=[C:45]([C:42]3[CH:41]=[CH:40][C:39]([O:38][CH2:37][O:36][CH3:35])=[CH:44][CH:43]=3)[N:50]=[C:49]3[N:51]([CH:55]4[CH2:60][CH2:59][CH2:58][CH2:57][O:56]4)[N:52]=[C:53]([CH3:54])[C:48]=23)[CH2:67][C:66]1([CH3:69])[CH3:68]

Participants

4

Reactant 3

HCID 60984Methyl bromoacetateHCID 90013940HCID 90013940, compoundHCID 178501522HCID 178501522, compound

Product 1

HCID 90013949HCID 90013949, compound

Procedure

The title compound was prepared in analogy to Example 74 ({4-[6-(2-Fluoro-4-hydroxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-ylmethyl]-2,2,5,5-tetramethyl-piperazin-1-yl}-acetic acid methyl ester employing 6-(4-Methoxymethoxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-4-(2,2,5,5-tetramethyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridine and methyl bromoacetate and was used without further purification.

Workup

  1. customwas used without further purification

Sources & evidence

ORD record
ord-5cc59081fe7442bc843627708c89e076
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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