Hydrochloric Acid → 3,3-Dimethyl-1-(phenylmethyl)piperazine

HRID 2279172Notes

Reaction equation

HRID 2279172 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10][C:9]1([CH3:22])[CH3:21])=O)(C)(C)C.Cl>CO>[CH2:14]([N:11]1[CH2:12][CH2:13][NH:8][C:9]([CH3:22])([CH3:21])[CH2:10]1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 866803274-Benzyl-2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 594853523,3-Dimethyl-1-(phenylmethyl)piperazineYield 108.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.30 g of 4-benzyl-2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester were dissolved in 50 ml methanol, and 25 ml of 1N aqueous hydrochloric acid were added. After stirring overnight 5 ml of concentrated aqueous hydrochloric acid were added. After 2 h the volatiles were removed in vacuo and 2.40 g (97%) of the title compound were obtained as hydrochloride salt, which could be use without further purification.

Workup

  1. additionwere added
  2. customAfter 2 h the volatiles were removed in vacuo

Sources & evidence

ORD record
ord-dddd203315e24c99b6fafe5058efe316
Source dataset
uspto-grants-2015_09
Patent number
US09133181B2

Reaction notes

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