Potassium Carbonate → HCID 117858047, compound

HRID 2279208Notes

Reaction equation

HRID 2279208 reaction equation
C([O:4][C:5]1[CH:29]=[CH:28][CH:27]=[CH:26][C:6]=1[C:7]([NH:9][C:10]1[S:22][C:13]2[C:14]([CH3:21])([CH3:20])[O:15][C:16]([CH3:19])([CH3:18])[CH2:17][C:12]=2[C:11]=1[C:23]([NH2:25])=[O:24])=[O:8])(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.O1CCOCC1>[OH:4][C:5]1[CH:29]=[CH:28][CH:27]=[CH:26][C:6]=1[C:7]([NH:9][C:10]1[S:22][C:13]2[C:14]([CH3:21])([CH3:20])[O:15][C:16]([CH3:18])([CH3:19])[CH2:17][C:12]=2[C:11]=1[C:23]([NH2:25])=[O:24])=[O:8]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 117857904HCID 117857904, compound

Product 1

HCID 117858047HCID 117858047, compound

Reagents, catalysts & solvents 1

HCID 21966525Dioxane MethanolSolvent

Procedure

To a solution of 2-(2-acetoxybenzamido)-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide (200 mg, 0.48 mmol) in 4 mL of MeOH/dioxane=1:1, cooled to 0° C., is added potassium carbonate (66 mg, 0.52 mmol). The reaction mixture is stirred at room temperature for 90 min, filtered off and filtrate is then acidified with 1M HCl. A precipitate is formed which is separated by filtration to afford the desired compound which is used as such.

Workup

  1. filtrationfiltered off
  2. customA precipitate is formed which
  3. customis separated by filtration

Sources & evidence

ORD record
ord-ba11bee472d343418a25beb4d5509678
Source dataset
uspto-grants-2015_09
Patent number
US09133210B2

Reaction notes

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