2-Tetrahydropyranyl 4-benzyloxycarbonylaminobicyclo[2,2,2]octane-1-carboxylate → 2-Tetrahydropyranyl 4-aminobicyclo[2,2,2]octane-1-carboxylate

HRID 227932ノート

反応式

HRID 227932 の反応式
C(OC([NH:11][C:12]12[CH2:19][CH2:18][C:15]([C:20]([O:22][CH:23]3[CH2:28][CH2:27][CH2:26][CH2:25][O:24]3)=[O:21])([CH2:16][CH2:17]1)[CH2:14][CH2:13]2)=O)C1C=CC=CC=1.[H][H]>C(O)C.[C].[Pd]>[NH2:11][C:12]12[CH2:17][CH2:16][C:15]([C:20]([O:22][CH:23]3[CH2:28][CH2:27][CH2:26][CH2:25][O:24]3)=[O:21])([CH2:18][CH2:19]1)[CH2:14][CH2:13]2

参加物

5

反応物 2

HCID 231496802-Tetrahydropyranyl 4-benzyloxycarbonylaminobicyclo[2,2,2]octane-1-carboxylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 231496982-Tetrahydropyranyl 4-aminobicyclo[2,2,2]octane-1-carboxylate収率 99.6%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

2-Tetrahydropyranyl 4-benzyloxycarbonylaminobicyclo[2.2.2]octane-1-carboxylate (548 mg) was dissolved in ethanol (6 mL). To this solution, 10% palladium-carbon (60 mg) was added and the mixture was stirred at room temperature for 2 hours in a stream of hydrogen. The catalyst in the reaction mixture was filtered through a Celite pad and the filtered catalyst, together with the Celite pad, washed with ethanol. The filtrate and the washings were combined and concentrated under reduced pressure. The resulting residue was dried under reduced pressure to give 2-tetrahydropyranyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (357 mg).

後処理

  1. filtrationThe catalyst in the reaction mixture was filtered through a Celite pad
  2. washthe filtered catalyst, together with the Celite pad, washed with ethanol
  3. concentrationconcentrated under reduced pressure
  4. customThe resulting residue was dried under reduced pressure

出典と根拠

ORDレコード
ord-4da56854f69b40ecaf4b601b150c63d6
出典データセット
uspto-grants-2009_07
特許番号
US07560569B2

反応ノート

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