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HRID227948

反应详情

EQUATION

反应方程式

HRID 227948 的结构方程式

REACTANTS

反应物

2
结构：OC1CCNCC1
HCID79341

Piperidin-4-ol

C5H11NO

结构：N#C[C@@H]1C[C@H](F)CN1C(=O)CN(C(=O)OCc1ccccc1)C12CCC(C(=O)On3nnc4ccccc43)(CC1)CC2
HCID57756828

未命名化合物

PRODUCTS

生成物

1
结构：N#C[C@@H]1C[C@H](F)CN1C(=O)CN(C(=O)OCc1ccccc1)C12CCC(C(=O)N3CCC(O)CC3)(CC1)CC2
HCID68847303

未命名化合物

收率 82.9%

PROCEDURE

实验过程

In a similar manner to Example 4, (2S,4S)-1-[[N-benzyloxycarbonyl-N-[4-(benzotriazol-1-yl)oxycarbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 4-hydroxypiperidine (11.7 mg) were used to obtain (2S,4S)-1-[[N-benzyloxycarbonyl-N-[4-(4-hydroxypiperidin-1-yl)carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (39.0 mg).