Trifluoroacetic acid → HCID 68294693, compound

HRID 2279499Notes

Reaction equation

HRID 2279499 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[N:10]=[CH:11][C:12]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][C:13]=3[N:14]=2)[CH:5]=[CH:4][N:3]=1.C(O)(C(F)(F)F)=O>>[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[N:10]=[CH:11][C:12]3[CH2:18][CH2:17][NH:16][CH2:15][C:13]=3[N:14]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68294290HCID 68294290, compound

Product 1

HCID 68294693HCID 68294693, compound

Procedure

A solution of 188 (136 mg, 0.398 mmol) and TFA (2 mL) was stirred for 15 min. The reaction was concentrated to afford N-(2-methylpyridin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-amine (190) which was used without additional purification.

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-f1dd7521efe34c3386be4c4a748e207c
Source dataset
uspto-grants-2015_09
Patent number
US09133187B2

Reaction notes

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